Endocrine Abstracts

Introduction: Knowledge about end-user perceptions is important to ensure educational resources have maximal impact.Objective: To understand school children’s perceptions and ideas about three endocrine topics.Methods: This activity was done as part of Society for Endocrinology public engagement grant. Years 5 and 6 school children (aged 10-11 years) from Nonsuch Primary School in Birmingham were invited to create posters on t...

Background: In women, androgen excess is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). Androgen precursors are released from the adrenal gland and converted to active androgens in peripheral tissues including adipose tissue. Although the liver plays a key role in all metabolic processes in the body, its involvement in androgen metabolism is yet to be explored. Here, we describe the investigation of androgen metabolism in human liver using norm...

Introduction: Polycystic ovary syndrome affects 10% of women and comes with a 2-3fold increased risk of type 2 diabetes, hypertension, and fatty liver disease. Androgen excess, a cardinal feature of PCOS, has been implicated as a major contributor to metabolic risk. Adrenal-derived 11-oxygenated androgens represent an important component of PCOS-related androgen excess and are preferentially activated in adipose tissue. We aimed to identify PCOS sub-types with distinct androge...

Introduction: Polycystic ovary syndrome (PCOS) affects 10% of women and is associated with a 2-3fold risk of type 2 diabetes (T2D), hypertension, fatty liver and cardiovascular disease. Androgen excess has been implicated as a major contributor to metabolic risk in PCOS. We aimed to identify PCOS sub-types with distinct androgen profiles and compare their cardiometabolic risk.Methods: We cross-sectionally studied 488 tre...